Mechanism of Action

RADIESSE® Volumizing Filler is an injectable implant composed of smooth calcium hydroxylapatite (CaHA) microspheres (diameter of 25 µm to 45 µm) suspended in a sodium carboxymethylcellulose gel carrier. RADIESSE Volumizing Filler is approximately 30% CaHA and 70% gel carrier by volume.

RADIESSE Volumizing Filler is injected under the skin in a minimally invasive procedure. Injection of the product provides an immediate and visible correction to the wrinkle. There is no skin sensitivity testing or reconstitution required.

Over time, the gel is absorbed, and fibroblasts appear. The process of neocollagenesis begins, stimulating the gradual growth of the patient’s own collagen.1 The collagen that forms results in extended correction and increased patient satisfaction. Results are clinically proven to last a year or more in many patients.2,3

RADIESSE Histology Slides

Histology slides demonstrate deposition of new collagen around CaHA microspheres over an extended period of time. Collagen fibers stain red, while other tissue elements appear more yellow.1

The cosmetic results are soft and natural-looking, and feel like the patient’s own tissue. The correction is long-lasting, but not permanent. The CaHA microspheres naturally degrade to calcium and phosphate ions, which are metabolized by the body’s normal processes.2,3

How It Works

If you would like more information about becoming a RADIESSE Volumizing Filler provider, contact us.

1. Berlin AL, Hussain M, Goldberg DJ. Calcium hydroxylapatite filler for facial rejuvenation: a histologic and immunohistochemical analysis. Dermatol Surg. 2008;34:S64-S67.

2. Moers-Carpi M, Vogt S, Santos BM, et al. A multicenter, randomized trial comparing calcium hydroxylapatite to two hyaluronic acids for treatment of nasolabial folds. Dermatol Surg. 2007;33:S144-S151.

3. Bass LS, Smith S, Busso M, McClaren M. Calcium hydroxylate (Radiesse) for treatment of nasolabial folds: long-term safety and efficacy results. Aesthetic Surg J. 2010;30:235-238.